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Nonetheless, it does appear that hearts from insulin-resistant animals have an enlargement of the coronary LPL pool (), and acute and chronic moderate diabetes induced with streptozotocin is associated with an increased heparin-releasable LPL activity (, ), which could potentially contribute to the elevated rates of fatty acid β-oxidation.

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In addition, the total activity and the activation state of PDH, the key enzyme regulating myocardial pyruvate oxidation (and hence glucose and lactate oxidation), was not affected by HF.

For example, in canine perfused right atrial preparations, ranolazine alone or dronedarone alone reduced persistent AF by 29% or 17%, respectively, whereas the combination of the two drugs was found to suppress persistent AF by 90%.

Ranolazine is a selective inhibitor of late sodium current with anti-ischaemic and metabolic properties.

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Echocardiographic stress tests are not recommended as screening tools, but many doctors use these tests to confirm a clinical diagnosis of CAD in unclear cases.

Additional file 2: Figure S1: MDA-MB-231-shCTL cells expressing luciferase gene were seeded at different densities then treated for 24h with Ranolazine (50 μM, red circles) or not (black squares).

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Quality of life after coronary angioplasty or continued medical treatment for angina: three-year follow-up in the RITA-2 trial.

GW610742X switched substrate oxidation from fatty acids to carbohydrate but had little effect on the mRNA expression of fatty acid metabolism enzymes and did not affect LV chamber enlargement or progression of heart failure ().

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