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Philadelphia chromosome-positive chronic myeloid leukaemia (CML) is a hematologic disorder caused by an acquired abnormality in the DNA of the stem cells in the bone marrow.

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Acknowledgment: The authors thank Aysegul Gozu, MD, MPH, from the AHRQ; Meera Viswanathan, PhD, and Loraine Monroe, from RTI International, for dedicated support; and Irma Klerings, from Danube University, Krems, for literature searches.

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