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The purpose of this report is to review the clinical efficacy of pre-endoscopic intravenous proton pump inhibitors (PPI) for patients with upper gastrointestinal bleeding (UGIB) and to review the evidence-based guidelines regarding the use of proton pump inhibitors before endoscopy in patients with UGIB.

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Acute interstitial nephritis has been observed in patients taking PPIs including pantoprazole sodium.

PPI treatment, leaving a potential risk of residual confounding even after multivariable adjustment and propensity score analysis.

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