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The most likely manifestations of overdosage are expected to be hypotension and tachycardia; bradycardia might also occur from overdose.
Losartan potassium and hydrochlorothiazide tablets and certain other medicines may interact with each other.
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In patients with renal disease, thiazides may precipitate azotemia.
Hydrochlorothiazide is eliminated primarily by renal pathways.
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But the drug can have side effects such as abdominal cramping, elevated blood sugar and lowered potassium, so some patients prefer to discontinue use, particularly if they are managing their hypertension effectively through diet and exercise.
Meta-analysis of clinical trials associating thiazide-induced hypokalemia with hyperglycemia and attenuation of hyperglycemia with potassium treatment.
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Paracentesis is the treatment of choice in patients with grade 3 ascites and should be used in conjunction with sodium restriction and diuretic therapy.
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Triple therapy is then of all three groups and should the need arise then to add in a fourth agent, to consider either a further diuretic (e.
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