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I have been receiving Zometa via IV infusion for about 3 years now - At first three weekly then after about a year, four weekly - I have breast cancer, bone metastasis. If I take the infusion over 15 minutes....during the following day I will begin with severe vomiting and flu symptoms which last for two days and nights after which I'm fine. However, if I have the infusion over 30 minutes - as advised on the internet way back in the early days of my treatments, I have NO side effects whatsoever - no sickness, no aches & pains! I have spoken to other women who have experienced the same - take the infusion slower, drink plenty of water, and you might just find your horrid side-effects disappear!
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I dreaded the side-effects and had NONE. I had the intravenous infusion three days before Christmas 2011 and was scared that I would be flattened by the supposed side-effects like flu-like symptoms, bone ache and so forth and was pleasantly surprised. I am having my second one in just ten days time and hopefully it will be a repeat of the first one.

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Oddly, there are more complications on the Australia drug sheet for Aclasta (which is the name for Reclast used overseas) than you will see on the US Drug sheet under the FDA, and one of the complications is Basal Cell Carcinoma.

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This article was updated on 31 March 2015 to clarify that ustekinumab targets both IL12 and IL23.

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Studies do not support any significant benefit for use beyond 6 years of treatment.

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However, it is still not clear to me what would be the suggested "protocol" regarding a "real" patient that had already been administered Reclast a half a year ago, and i have to extract her two upper molars?

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