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These reactions are probably due to allergic and inflammatory responses to the death of microfilariae.

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PR-mediated progesterone signaling is anti-mitogenic in endometrial epithelial cells, and as such, mitigates the tropic effects of estrogen on eutopic normal endometrium, and on ectopic implants in endometriosis.

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To avoid bradycardia and other side effects, treatment with glycopyrrolate before physostigmine administration is advisable.

Ivermectin is a member of the avermectin class of broad-spectrum antiparasitic agents which have a unique mode of action.

In an open label study, 397 women in their second trimester of pregnancy were treated with ivermectin tablets and albendazole at the labeled dose rate for soil-transmitted helminths and compared with a pregnant, non-treated population.

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In October 2014, we searched the following databases: MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, CINAHL, Psychology and Behavioral Sciences Collection, Agricola, and Food Science Source.

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It is now believed that the drug actually disrupts the fundamental host-parasite equilibrium.

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Notably, ivermectin also induced the recruitment of corepressor NCoR-2 by FXR, which is distinct from GW4064 ().

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As lowest levels of dermal microfilariae occur well after this timeframe, it suggests that not all microfilariae affected by ivermectin are killed in the first few days.

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Efficacy, as measured by cure rate, was defined as the absence of larvae in at least two follow-up stool examinations 3 to 4 weeks post-therapy.

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The dosages of ivermectin in heartworm preventives are significantly lower than doses used for other purposes.

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Ivermectin Injection has been proved to effectively control infections and to protect cattle from reinfection with Dictyocaulus viviparus for 28 days after treatment; Ostertagia ostertagi for 21 days after treatment; Oesophagostomum radiatum, Haemonchus placei, Trichostrongylus axei, Cooperia punctata and Cooperia oncophora for 14 days after treatment.

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To validate the roles of pocket residues in ivermectin binding and FXR activation, we mutated several key residues that contact different groups of ivermectin and tested the transcriptional activity of these mutated FXR in response to ivermectin in cell-based reporter assays using full-length FXR and the EcRE reporter.

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Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin.

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The rationale for the treatment of genitourinary myiasis is to remove the offending larvae.

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False-positive results from cross-reactivity with other parasites have not been seen.

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